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Buy cannabis ADB-FUBINACA online. (also known as 5F-MDMB-PINACA or 5F-ADB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug.[1] 5F-ADB is a potent agonist of the CB1 receptor,[2] though it is unclear whether it is selective for this target. 5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance. Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.[3]

In 2018, 5F-ADB was the most common synthetic cannabinoid to be identified in Drug Enforcement Administration seizures.[4] 5F-ADB was also identified in cannabidiol (CBD) products from a US-based CBD manufacturer in 2018
ADB-FUBINACA is a designer drug identified in synthetic cannabis blends in Japan in 2013.[1] In 2018, it was the third-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Administration.[2]

The (S)-enantiomer of ADB-FUBINACA is described in a 2009 Pfizer patent[3] and has been reported to be a potent agonist of the CB1 receptor and the CB2 receptor with EC50 values of 1.2 nM and 3.5 nM, respectively.[3][4] ADB-FUBINACA features a carboxamide group at the 3-indazole position, like SDB-001 and STS-135. ADB-FUBINACA appears to be the product of rational drug design, since it differs from AB-FUBINACA only by the replacement of the isopropyl group with a tert-butyl group.

An analogue of ADB-FUBINACA, ADSB-FUB-187, containing a more functionalized carboxamide substituent was recently reported.

Contents
1 Side effects
2 Metabolism
3 Legality
4 See also
5 References
Side effects
One death through coronary arterial thrombosis has been linked to ADB-FUBINACA intoxication.[5]

At least an additional 8 deaths in Hungary in 2015 are linked to the usage of this material, all deaths were youngsters below 21.

Metabolism
Twenty-three ADB-FUBINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic pathways were alkyl and indazole hydroxylation, terminal amide hydrolysis, subsequent glucuronide conjugations, and dehydrogenation.

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